Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

Blog Article

Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro.In addition to their known anticoagulants activity this potential inhibition could have volcano crisps an additional therapeutic effect on patients with COVID-19 disease.In this study we examined the binding of the Apixaban, Betrixaban and Rivaroxaban to the SARS-CoV-2 Mpro with the use of the MicroScale Thermophoresis technique.

Our results indicate that the experimentally measured binding affinity is weak and the fp9550bk therapeutic effect due to the SARS-CoV-2 Mpro inhibition is rather negligible.